Safety of efavirenz in the first trimester of pregnancy an updated systematic review and meta-analysis.

Safety of efavirenz in the first trimester of pregnancy an updated systematic review and meta-analysis.

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Efavirenz is one of the most widely used nonnucleoside reverse transcriptase inhibitors (NNRTIs) in first-line antiretroviral therapy (ART) and is recommended as a preferred option in adult treatment guidelines. However, data from primate studies and some human case reports have raised concern regarding a association ...

Interventions to improve adherence to antiretroviral therapy a rapid systematic review.

Interventions to improve adherence to antiretroviral therapy a rapid systematic review.

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Antiretroviral treatment (ART) has converted a highly fatal HIV infection into a chronic condition that requires lifelong care. Within the past decade, worldwide access to ART has improved significantly, with almost 10 million people receiving ART by the end of 2012. In addition to its ...

Integrating collaborative TB and HIV services within a comprehensive package of care for people who inject drugs.

Integrating collaborative TB and HIV services within a comprehensive package of care for people who inject drugs.

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People who inject drugs (PWID) are at increased risk of tuberculosis (TB). HIV further increases the risk of developing TB, with TB being a leading cause of mortality among PWID who live with HIV. Much of the evidence relates to TB among PWID; however, people ...

Improving antiretroviral therapy scale-up and effectiveness through service integration and decentralization.

Improving antiretroviral therapy scale-up and effectiveness through service integration and decentralization.

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Global efforts to scale up antiretroviral therapy (ART) between 2002 and 2012 averted an estimated 4.2 million deaths in low-income and middle-income countries. The United Nations endorsed the importance of this impact and agreed to scale up ART to 15 million people by 2015. In ...

Getting it right WHO guidance to diagnose correctly 90% of people living with HIV.

Getting it right WHO guidance to diagnose correctly 90% of people living with HIV.

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Aims of the new WHO HTS guidelines Addressing the testing gap Getting testing out intocommunities Supporting better linkage Better focus and appropriate targeting Improving quality to prevent misdiagnosis

Early initiation of antiretroviral therapy in HIV-infected adults and adolescents a systematic review.

Early initiation of antiretroviral therapy in HIV-infected adults and adolescents a systematic review.

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The optimal timing for initiating antiretroviral therapy (ART) in individuals infected with HIV-1 has not yet been resolved. The US Department of Health and Human Services and the International Antiviral Society – USA recommend starting ART as close to diagnosis as possible. France and Brazil ...

Developing the 2013 WHO consolidated antiretroviral guidelines.

Developing the 2013 WHO consolidated antiretroviral guidelines.

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The 2013 ‘Consolidated guidelines on the use of antiretroviral (ARV) drugs for treating and preventing HIV infection’, released in July 2013, are the latest and most comprehensive of a series of important guidelines on antiretroviral therapy (ART) over the last decade from the World Health ...

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2016. 2nd eddition

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2016. 2nd eddition

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With this update of the consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, WHO, for the first time, recommends that all people living with HIV be provided with antiretroviral therapy (ART). This will bring us one step closer to ...

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2015.

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2015.

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The second edition of the World Health Organization (WHO) consolidated guidelines on the use of antiretrovirals (ARVs) updates the 2013 edition following an extensive review of evidence undertaken in 2015. Experience from country programmes, consultations with communities and modelling of potential impact have informed the ...

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2013.

Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2013.

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These consolidated guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the care of people living with HIV and the use of antiretroviral (ARV) drugs for treating and preventing HIV infection. They are structured along the continuum of HIV testing, care and ...

Community and service provider views to inform the 2013 WHO consolidated antiretroviral guidelines key findings and lessons learn.

Community and service provider views to inform the 2013 WHO consolidated antiretroviral guidelines key findings and lessons learn.

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Objective: The objective was to evaluate community and healthcare worker (HCW) values and preferences on key topics to inform the development of the 2013 WHO consolidated guidelines for antiretroviral therapy in low and middle income countries. Design: Cross-sectional e-survey and e-forum discussion; focus group discussions (FGDs) Methods: ...

Commentary operational guidance in the 2013 WHO consolidated antiretroviral guidelines.

Commentary operational guidance in the 2013 WHO consolidated antiretroviral guidelines.

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In June 2013, the WHO released consolidated guidelines on the use of antiretrovirals (ARVs) . The launch of these new guidelines is another milestone in the global endeavor toward universal access to antiretroviral treatment (ART) using the public health approach, pursuing the dual advantage of ...

Commentary antiretroviral therapy initiation criteria in low resource settings – from ‘when to start’ to ‘when not to start’.

Commentary antiretroviral therapy initiation criteria in low resource settings – from ‘when to start’ to ‘when not to start’.

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By the end of 2012, the number of people receiving antiretroviral treatment (ART) in low and middle-income countries reached 9.7 million, including 7.2 million in sub-Saharan Africa. The bad news is that these figures represent only 65% of the global target of 15 million people ...

Adoption of national recommendations related to use of antiretroviral therapy before and shortly following the launch of the 2013 WHO consolidated guidelines.

Adoption of national recommendations related to use of antiretroviral therapy before and shortly following the launch of the 2013 WHO consolidated guidelines.

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Objective: To determine the status of key national policies on the use of antiretroviral therapy (ART) at the time of the launch of the 2013 WHO consolidated guidelines as well as to track early progress towards adoption of these recommendations following dissemination. Design: Descriptive analysis of ...

WHO. MhGAP intervention guide for mental, neurological and substance use disorders in non-specialized health settings.

WHO. MhGAP intervention guide for mental, neurological and substance use disorders in non-specialized health settings.

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Mental Health Gap Action Programme (mhGAP) – background About four out of five people in low- and middle-income countries who need services for mental, neurological and substance use conditions do not receive them. Even when available, the interventions often are neither evidence-based nor of high quality. ...

Update on PQ programme and regional harmonization of drug registration 2015.

Update on PQ programme and regional harmonization of drug registration 2015.

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The Prequalification of Medicines Programme (PQP) • A United Nations Programme managed by WHO • Started in March 2001 as a Pilot Project: Focus on HIV/AIDS • Partners included WHO, UNICEF, UNFPA, UNAIDS and supported by World Bank • Quickly expanded to include Tuberculosis, Malaria, Reproductive Health, Influenza and ...