Regulus announces continuation of RG-101 clinical hold

Regulus Therapeutics Inc. (Nasdaq: RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced that it received written communication from the U.S. Food and Drug Administration (FDA) that the clinical development program for RG-101 remains on clinical hold. In ...

January 31, 2017
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EUPATI All Aboard to a Better Health Future – presentations online

On December 14 2016, the closing EUPATI workshop named “All Aboard to a Better Health Future” took place in Brussels. The meeting presented the achievements, learnings, goals, work done, accomplishments, as well as plans for the future sustainability and continuation of the EUPATI toolbox, trainings, ...

January 31, 2017

Final yes from NICE for Gilead’s Epclusa

The National Institute for Health and Care Excellence has now published final guidance endorsing Epclusa as an option for the treatment of adults with chronic hepatitis C genotype 1-6 infection on the NHS in England and Wales. Epclusa – a once-daily, fixed-dose combination of the nucleotide ...

January 27, 2017
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Alliance starts treating hepatitis C with the combination of sofosbuvir/ledipasvir

Currently most effective directly-acting antiviral agent for hepatitis C (HCV) treatment has already arrived to Ukraine! Alliance for Public Health launches the third phase of HCV treatment program for key populations. This phase stipulates using a direct-acting antiviral agent, which is new for Ukraine – Harvoni ...

January 26, 2017
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Food is medicine for HIV-positive and type 2 diabetes patients

Study finds good nutrition improves medication adherence and mental health HIV-positive people who received healthy food and snacks for six months were more likely to adhere to their medication regimens, and they, as well as people with type 2 diabetes, were less depressed and less likely ...

January 26, 2017
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New and touted HIV bNAb: Big deal or news blip?

Fervid research has uncovered dozens of antibodies that shield cells from HIV. These broadly neutralizing antibodies (bNAbs) protect monkeys from SHIV, the simian-HIV hybrid. Thousand-person human trials are already dripping bNAbs into high-risk men and women to see if they prevent HIV infection. And much ...

January 26, 2017
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Antibody combination puts HIV on the ropes

Without antiretroviral drug treatment, the majority of people infected with HIV ultimately develop AIDS, as the virus changes and evolves beyond the body’s ability to control it. But a small group of infected individuals—called elite controllers—possess immune systems capable of defeating the virus. They accomplish ...

January 26, 2017
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Medicines Patent Pool announces first licence for TB treatment

In an effort to improve the international response to combatting multidrug-resistant TB, MPP and Johns Hopkins University sign licensing agreement for investigational treatment sutezolid Geneva, 25 January 2017 — The Medicines Patent Pool today announced that it has signed a licence with Johns Hopkins University ...

January 26, 2017
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EMA grants accelerated assessment, validates Marketing Authorization Application for AbbVie’s investigational hepatitis C therapy

European Medicines Agency grants accelerated assessment, validates Marketing Authorization Application for AbbVie’s investigational regimen of glecaprevir/pibrentasvir (G/P) for the treatment of chronic hepatitis C in all major genotypes (GT1-6) – If approved, G/P may provide a shorter, eight week, once-daily, ribavirin-free treatment option for the majority ...

January 25, 2017
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Gene therapy to cure HIV: Where to from here?

Gene therapy — which involves modifying genetic material, such as DNA and RNA — holds exciting potential as a cure for numerous diseases and conditions, including HIV. Timothy Brown (the “Berlin patient”) remains the only person known to have been cured of HIV. Brown received a ...

January 25, 2017
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Cognitive decline in hepatitis C could be influenced by interferon treatment

A group of researchers is investigating whether or not interferon-free therapy could reverse the cognitive declines that appear to accompany infection with the hepatitis C virus (HCV), with or HIV coinfection. Felix Kleefeld, of Berlin, Germany, and colleagues examined how eradicating HCV affected the cognition of ...

January 24, 2017
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Immediate ART for HIV protects against severe bacterial infections

Initiating, rather than deferring, antiretroviral therapy (ART) reduces the risk of severe bacterial infections in HIV-positive individuals with high CD4 counts, researchers say. Their data are from the START trial, which showed a 57% reduction in the risk of AIDS and non-AIDS morbidity and mortality in ...

January 24, 2017
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