This manual aims to contribute to the comprehensive response to HIV, TB and drug use and support linkages between HIV prevention, TB control and harm reduction strategies and services in Eastern Europe and Central Asia. It compiles clinical and programmatic information about TB, HIV and drug use aligned with the most recent normative guidance issued by WHO.  The goal of the manual is to increase the capacity to provide quality TB-related services for people who inject drugs and are living with HIV.  Although the training manual might be useful for all stakeholders involved in harm reduction and TB programs as an information resource, it is primarily designed for trainers developing and delivering trainings to civil society, community and health care workers in the field of harm reduction, TB and HIV.