Over a period of 1988–2013 in the Republic of Armenia there were 1619 registered cases of HIV infection (cumulative data). The estimated number of PWLH in the Republic of Armenia constituted 3700 in 2013. There was a growth in the number of newly registered cases of HIV infection: in 2011 there were 182 newly registered cases of HIV infection, in 2012 and 2013 there were 228 and 238 cases correspondingly. The indicators of HIV infection spread imply stabilization of the epidemiological process among key vulnerable groups such as PWID, MSM and CSW in the Republic of Armenia.