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In 2004, European and Central Asian countries held a high-level conference ‘Breaking the Barriers – Partnership to fight HIV/AIDS in Europe and Central Asia.’ The conference resulted in the Dublin Declaration, which aimed to galvanise political action to tackle the epidemic in the region. This brief summarises what has been achieved since 2004, areas where there has been less progress, and priorities for future action. It draws on data reported by countries as part of their monitoring activities for the Dublin Declaration and for UNAIDS global reporting in 2010, 2012 and 2014, and on surveillance data reported by countries to ECDC and WHO’s Regional Office for Europe since 2004. In November 2014, the Italian Presidency to the EU Council will host a ministerial conference in Rome to reflect on achievements since the adoption of the Dublin Declaration in 2004 and to propose a new political declaration, focusing on aspects of the response that need attention.